The Li laboratory is based at Mass General Brigham (MGB) and affiliated with Harvard Medical School. We are focused on understanding viral persistence, evolution and drug resistance in a search for strategies for viral eradication and cure.  In particular, our lab has interests in studying HIV and respiratory viruses, and we use patient samples to answer clinically-relevant questions in the laboratory setting. We are highly collaborative, working with investigators across MGB, the Boston region, nationally through the CHAMP study & DARE Collaboratory, and internationally through the ACTG (Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections, formerly the AIDS Clinical Trials Group).

Dr. Jonathan Li is the Director of the Harvard/Brigham Virology Specialty Laboratory, the Director of the Harvard University Center for AIDS Research Clinical Core, and the Research Director for the BWH ID Fellowship. He also holds leadership positions in the ACTG as the Director of the ACTG Virology Core Laboratories, the Vice Chair of the ACTG HIV Reservoirs, Eradication and Cure Transformative Science Group and as the Chair of several ACTG clinical trials. He co-led the MGB biorepository efforts during COVID-19 for the Massachusetts Consortium for Pathogen Readiness (MassCPR) and serves on the MassCPR Steering Committee. He is a Deputy Editor for the Journal of Infectious Diseases. In addition, he sees patients in both the outpatient Infectious Diseases clinic and in the inpatient consult service at the Brigham and Women’s Hospital.

Current research projects include:

• Predictors of HIV rebound after treatment interruption and post-treatment virologic control
• Impact of HIV minority variants using next-generation sequencing
• HIV integration into the human genome
• Mechanisms and clinical impact of persistent low-level HIV viremia despite antiretroviral therapy
• Clinical and translational research in respiratory viruses

The Li Laboratory is located in Cambridge MA, and is part of Mass General Brigham and affiliated with Harvard Medical School.